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Journal of Antimicrobial Chemotherapy, Vol 39, 95-98, Copyright © 1997 by The British Society for Antimicrobial Chemotherapy

JOURNAL ARTICLE

In-vitro killing activity of combinations of beta-lactam agents with aminoglycosides against penicillin-resistant pneumococci

L Schlegel, G Sissia, A Fremaux and P Geslin
Centre National de Reference des Pneumocoques, Centre Hospitalier Intercommunal, Creteil, France.

Streptococcus pneumoniae has developed resistance to almost every antibacterial agent used in clinical practice, including the most active beta-lactams. This has led to the proposed use of drug combinations. The aim of this study was to determine the efficacy of combinations of beta-lactam agents (cefotaxime or imipenem) with aminoglycosides (gentamicin, netilmicin or amikacin) against pneumococci showing high-level resistance to penicillin and streptomycin and/or kanamycin. All tested combinations were bactericidal and synergic despite the weak concentrations of antibiotics used. Our results suggest that combinations of beta-lactam agents with aminoglycosides may be useful for treating infections by penicillin-resistant pneumococci located outside the central nervous system.
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