Journal of Antimicrobial Chemotherapy, Vol 39, 103-106, Copyright © 1997 by The British Society for Antimicrobial Chemotherapy
F Espinasse, R Gheorghiu, A Poiata, R Labia and MH Nicolas-Chanoine
By determining the beta-lactam susceptibility of Enterobacteriaceae
isolated in Eastern Romania from 1985 to 1993, three Escherichia coli,
three Salmonella typhimurium and one Klebsiella pneumoniae isolates with
reduced susceptibility to co-amoxiclav were found. The antibiotic
susceptibility of the isolates and their E. coli derivatives, and kinetic
values suggested the following resistance mechanisms: hyperproduction of
TEM in S. typhimurium, limited antibiotic uptake in K. pneumoniae and OXA
production in one strain of E. coli. Despite a normal beta-lactamase
activity, the two remaining E. coli strains and their derivatives were less
susceptible to co-amoxiclav.
JOURNAL ARTICLE
Reduced susceptibility to co-amoxiclav in Escherichia coli, Salmonella typhimurium and Klebsiella pneumoniae isolated in Romania between 1985 and 1993
Service de Microbiologie, Hopital Ambroise Pare, Faculte de Medecine Paris Ouest, Boulogne, France.
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