Skip Navigation

This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (6)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by García, I.
Right arrow Articles by Perea, E. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by García, I.
Right arrow Articles by Perea, E. J.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Journal of Antimicrobial Chemotherapy (1996) 38, 859-863
© 1996 The British Society for Antimicrobial Chemotherapy

brief-report

Effect of paclitaxel alone or in combination on the intracellular penetration and activity of quinolones in human neutrophils

Isabel García*, Alvaro Pascual, Javier Salvador, M. Carmen Conejo and Evelio J. Perea

Department of Microbiology, School of Medicine Apdo 914, Seville 41080, Spain

Received 4 April 1996; returned 17 May 1996; accepted 16 June 1996

*Fax: +34-5-4377413

We evaluated the effect of paclitaxel alone or in combination with cisplatin or doxorubicin, on the intracellular penetration and activity of ciprofloxacin, ofloxacin, levofloxacin and sparfloxacin in human polymorphonuclear leukocytes (PMN). In general, paclitaxel either alone or in combination did not affect the intracellular concentrations of the quinolones evaluated (intracellular to extracellular concentration ratio (C/E) >4). However, at high concentrations (20 mg/L) paclitaxel decreased the penetration of ofloxacin and levofloxacin although the C/E ratios remained higher than 3. Paclitaxel alone or in combination affected neither the production of oxygen radicals by PMN nor the intracellular activity of the quinolones against Staphylococcus aureus.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J Antimicrob ChemotherHome page
A. C. Williams, H. F. Galley, A. M. Watt, and N. R. Webster
Differential effects of three antibiotics on T helper cell cytokine expression
J. Antimicrob. Chemother., September 1, 2005; 56(3): 502 - 506.
[Abstract] [Full Text] [PDF]

Home page
 Antimicrob. Agents Chemother.Home page
D. Vazifeh, A. Bryskier, and M.-T. Labro
Mechanism Underlying Levofloxacin Uptake by Human Polymorphonuclear Neutrophils
Antimicrob. Agents Chemother., February 1, 1999; 43(2): 246 - 252.
[Abstract] [Full Text]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.