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Journal of Antimicrobial Chemotherapy (1996) 37, 403-421
© 1996 The British Society for Antimicrobial Chemotherapy

review-article

Antiviral resistance: mechanisms, clinical significance, and future implications

David W. Kimberlin and Richard J. Whitley

Department of Pediatrics, The University of Alabama at Birmingham 1600 Seventh Avenue South, Suite 616, Birmingham, AL 35233, USA

Received 2 May 1995; returned 9 October 1995; accepted 18 November 1995

The increased awareness of antiviral resistance over the past decade has paralleled the development of new antiviral agents. While such resistant viral isolates are of clinical significance primarily in immunocompromised individuals, the development and transmission of such mutants have been reported in immunocompetent persons as well. As antiviral agents are increasingly utilised by the clinician, the incidence of such occurrences is likely to increase. Issues relating to mechanisms of antiviral resistance, clinical manifestations and significance of resistance, and implications for future antiviral development and utilisation are reviewed in this article. Viruses that are discussed include herpes simplex virus, varicella-zoster virus, cytomegalovinis, influenza A virus, and human immunodeficiency virus.


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