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Journal of Antimicrobial Chemotherapy (1996) 37, 357-359
© 1996 The British Society for Antimicrobial Chemotherapy

brief-report

In-vitro activity of 3-azinomethyl-rifamycin (SPA-S-565) against Chlamydia trachomatis

S. Zanettia, D. Usaia, A. Nonisb and G. Faddaa

aInstitute of Microbiology and Virology, University of Sassari Viale S. Pietro, 43/B Sassari bMedical Direction SPA-Società Prodotti Antibiotici S.p.A. Via Biella 8, 20143, Milan, Italy

Received 24 March 1995; returned 13 June 1995; accepted 19 September 1995

The in-vitro activity of a 3-azinomethyl-rifamycin (SPA-S-565) against Chlamydia trachomatis was compared to that of rifampicin and of erythromycin. The compound showed excellent activity for standard strains as well as isolates from patients with sexually transmitted diseases, being more active than the other drugs tested.

SPA-S-565 also showed a low frequency of emergence of resistance. Passage of standard strains at sub-inhibitory concentrations caused an increase in MIC values of rifampicin while those for SPA-S-565 remained unchanged.


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