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Journal of Antimicrobial Chemotherapy (1996) 37, 351-356
© 1996 The British Society for Antimicrobial Chemotherapy

brief-report

Mutations of the gyrA gene of clinical isolates of Salmonella typhimurium and three other Salmonella species leading to decreased susceptibilities to 4-quinolone drugs

J. C. Brown, C. J. Thomson and S. G. B. Amyes*

Department of Medical Microbiology, The Medical School, University of Edinburgh Teviot Place, Edinburgh EH8 9AG, UK

Received 19 April 1995; returned 15 August 1995; accepted 27 September 1995

*Corresponding author

The region of the gyrA gene encoding nucleotides 72 to 557 in ten Salmonella tvphimurium clinical isolates received from Vellore, India and six British clinical isolates of a number of Salmonella species has been sequenced. Those exhibiting a decreased susceptibility to 4-quinolone drugs (MICs of ciprofloxacin ranging from 0.128 mg/L to 1.0 mg/L) have been shown to possess a number of different mutations in this region of the gene (Asp-87 to Gly, Asp-87 to Asn and Ser-83 to Phe). The mutations Asp-87 to Gly and Ser-83 to Phe/Asp-87 to Asn have yet to be reported occurring in S. typhimurium


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