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Journal of Antimicrobial Chemotherapy (1995) 36, 845-850
© 1995 The British Society for Antimicrobial Chemotherapy

brief-report

Activity of biapenem (LJC 10627) against 51 imipenem-resistant bacteria and selection and characterisation of biapenem-resistant mutants

L. J. V. Piddock and Y. F. Jin

Antimicrobial Agents Research Group, Department of Infection, The Medical School University of Birmingham Birmingham B15 2TT, UK

Received 13 February 1995; returned 31 May 1995; accepted 25 July 1995

For wild-type bacteria the activity of biapenem was similar to that of imipenem, but for 51 imipenem-resistant strains meropenem was more active than either. When penicillin-binding protein 2a (PBP 2a) was expressed in Staphylococcus aureus biapenem had reduced activity. Mutant bacteria with decreased susceptibility to biapenem were selected in agar. Most of the mutant Gram negative bacteria were unstable and readily reverted to susceptible. The mutant Proteus vulgaris and Pseudomonas aeruginosa lacked an outer membrane protein. Biapenem-resistant S. aureus could be selected only from MRSA.


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