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Journal of Antimicrobial Chemotherapy (1995) 36, 215-218
© 1995 The British Society for Antimicrobial Chemotherapy

brief-report

In-vitro activity of a new quinolone (CP-99, 219) compared with ciprofloxacin, pefloxacin, azithromycin and penicillin against Neisseria gonorrhoeae

J. H. van Rijsoort-Vosa, E. Stolzb, H. A. Verbnigha and J. A. J. W. Kluytmansa,*

aDepartments of Clinical Microbiology, University Hospital Rotterdam The Netherlands bDepartments of Dermato-venereology, University Hospital Rotterdam The Netherlands

Received 22 November 1994; accepted 23 February 1995

*Corresponding author: Jan A. J. W. Kluytmans, University Hospital Rotterdam, Dijkzigt, Department of Clinical Microbiology, Dr. Molewaterplein 40, 3015 GD Rotterdam, the Netherlands. Phone:+ 31-(10)-4633510 Fax: +31-(10)-4633875

The in-vitro activities of CP-99, 219, ciprofloxacin, pefloxacin, azithromycin and penicillin was tested against 114 Neisseria gonorrhoeae strains. The MIG90s were: 0.008 mg/L (MIC range 0.001-0.06 mg/L) for CP-99, 219, 0.008 mg/L (MIC range 0.001-0.25 mg/L) for ciprofloxacin, 0.12 mg/L (MIC range 0.008-4 mg/L) for pefloxacin, 0.25 mg/L (MIC range 0.03-1 mg/L) for azithromycin and 16mg/L (MIC range 0.015-16 mg/L) for penicillin. The activity of CP-99, 219 against various N. gonorrhoeae isolates was comparable to ciprofloxacin.


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