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Journal of Antimicrobial Chemotherapy (1995) 35, 425-427
© 1995 The British Society for Antimicrobial Chemotherapy

brief-report

Comparing antimicrobial activity against resistant Pseudomonas aeruginosa using an index for the absence of cross-resistance

Keiichi Takigawa, Jiro Fujita*, Kiyoshi Negayama, Guang Xu, Yoshifumi Yamagishi, Hiroshi Miyawaki, Satoko Hojo, Yasufumi Yamaji and Jiro Takahara

First Department of Internal Medicine, Clinical Laboratory Kagawa Medical School Kagawa, 761-07, Japan

Received 16 February 1994; returned 17 June 1994; accepted 14 October 1994

*Corresponding author. Phone: +81 878 98 5111; FAX: +81 878 98 7109.

We devised an index to estimate the degree cross-resistance between piperacillin, ceftazidime, sulbactam/cefoperazone, amikacin, tobramycin, carumonam and imipenem against 139 separate clinical isolates of Pseudomonas aeruginosa. A negative value of the index indicated the cross-resistance whereas a positive value suggested the converse making the device an index for the absence of cross resistance (ACR). Using the ACR index, we identified pairs of antibioticsexhibiting the least degree of cross-resistance and therefore the highest potential for treating infections due to P. aeruginosa.


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