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Journal of Antimicrobial Chemotherapy (1994) 33, 223-230
© 1994 The British Society for Antimicrobial Chemotherapy

research-article

In-vitro activity of five ß-lactam/ß-lactamase inhibitor combinations against consecutive isolates of the Enterobacteriaceae and Pseudomonas aeruginosa

J. C. McLaughlina,*, A. L. Barryb, P. C. Fuchsc, E. H. Gerlachd, D. J. Hardye and M. A. Pfallerf

a University of New Mexico Medical Center Albuquerque, New Mexico 87106 b The Clinical Microbiology Institute Tualatin, Oregon 97062 c St. Vincent Hospital and Medical Center Portland, Oregon 97225 d St. Francis Regional Medical Center Wichita, Kansas 67214 e University of Rochester Medical Center Rochester, New York 14642 f Oregon Health Sciences University Portland, Oregon 97201, USA

Received 4 March 1993; accepted 31 August 1993

*Department of Pathology, University Hospital, 2211 Lomas Blvd., N.E. Albuquerque, NM 87106, USA.

Susceptibility tests were performed on 2402 of consecutive isolates of Enterobacteriaceae and 254 strains of Pseudomonas aeruginosa in five separate medical centres. Five ß-lactams were evaluated with and without a ß-lactamase inhibitor. The effect of different inhibitors was species specific and the rank order of decreasing efficacy against all enteric bacilli was: cefoperazone-sulbactam > piperacillin-tazobactam > cefoperazone > ticarcillin-clavulanic acid > piperacillin > co-amoxiclav > ampicillin-sulbactam > ticarcillin > ampicillin > amoxycillin.


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[Abstract] [Full Text]


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