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Journal of Antimicrobial Chemotherapy (1992) 30, 197-201
© 1992 The British Society for Antimicrobial Chemotherapy

research-article

Disposition of roxithromycin in the epididymis after repeated oral administration

Pierre Costaa, Francois Desclaux d'Arramonb, Anne Goubyb, Henri Navratila, Florence Genyc, Marc Galtierc and Francoise Bressolled,*

aService d'Urologie-Andrologie France bLaboratoire de Bactériologie France cLaboratoire de Pharmacocinétique, Pharmacie Carémeau, CHRU Ninies France dDépartement de Pharmacocinétique, Faculté de Pharmacie, Université de Montpellier I Montpellier, France

Received 3 December 1991; returned 16 March 1992; accepted 16 March 1992

*Correspondence to: Dr F. Bressofle

The epididymal penetration of roxithromycin was studied in order to evaluate the drug for use in the treatment of epididymo-orchitis. Seventeen patients hospitalized for surgery as part of treatment for prostatic adenoma or prostatic cancer were pre medicated orally with roxithromycin 150 mg bd for three days followed by 150 mg pre-operatively (3 h before surgical incision). Roxithromycin concentrations in serum and epididymis were determined by microbiological assay. The mean epidi dymal concentrations were 6·48±4·88 and 5·98±392 mg/kg for left and right epididymis respectively and the corresponding mean tissue/serum ratios 0·88±0·57 and 0·84±0·53. The wide intersubject variation in the concentration of roxithromycin found in serum and tissue is commonly seen with other macrolide antibiotics. The concentrations observed in this study in serum and tissue were greater than the MIC90s for Chiamydia trachomatis (0·25 to 1 mg/L), and Ureaplasma urealyticum (0·5 mg/L).


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