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Journal of Antimicrobial Chemotherapy (1991) 27, 663-668
© 1991 The British Society for Antimicrobial Chemotherapy

research-article

The phannacokinetics of cefuroxime axetil in the sick elderly patient

E. Ridgwaya, K. Stewartb, G. Raib, M. C. Kelseya,* and C. Bielawskab

aDepartments of Microbiology, Whittington Hospital London N19 5NF, UK bGeriatric Medicine, Whittington Hospital London N19 5NF, UK

Received 25 October 1989; accepted 18 January 1991

Corresponding author

The pharmacokinetics of cefuroxime axetil (RS3 formulation) were studied in 20 elderly patients following admission for lower respiratory or urinary tract infection. The mean age was 83·9 years. A 12-hourly dose of 250 mg was given for five days. The mean time to attain maximum serum concentration was 3.2 h with a mean peak concentration of 8·5 mg/1. The mean serum elimination half-life was 3.5 h and the AUC0–{infty}p 60.4 mg/h.l. There was no accumulation of the drug in the patients studied after five days treatment. The data suggest that the standard dosage regimen is adequate in the sick elderly patient.


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