Journal of Antimicrobial Chemotherapy (1988) 21, 737-744
© 1988 The British Society for Antimicrobial Chemotherapy
research-article |
Surveillance of the antibiotic susceptibility of non-penicillinase producing Neisseria gonorrhoeae in the Netherlands from 1983 to 1986
aNational Institute of Public Health and Environmental Protection P.O. Box 1, 3720 BA Bilthoven bMunicipal Health Service P.O. Box 20244, 1000 ME Amsterdam cWesteinde Hospital Lijnbaan 32, 2512 VA The Hague dLeijenburg Hospital Leyweg 275, 2545 CH The Hague eUniversity Hospital Rotterdam/Dijkzigt Dr. Molenwaterplein 40, 3015 GD Rotterdam, The Netherlands
Received 26 November 1987; accepted 9 February 1988
From 1983 to 1986 more than 2000 non-pènicillinase producing Neisseria gonorrhoeae from Amsterdam, The Hague and Rotterdam were auxotyped and screened for susceptibility to 10 antibiotics by MIC determination. By far the commonest auxotypes were N.R. (non-requiring; 40%) and Pro– (proline requiring; 30%). During that period there was a substantial shift in the ratio of both auxotypes-roughly from 1:2 to 2:1—in The Hague.
Pro– isolates were generally less susceptible than N.R. isolates, and there was a strong positive correlation between the MICs of the different drugs. The prevalence of isolates with a penicillin MIC equal to or above 0·5 IU/ml amounted to 14%, while in only 1% was the MIC above 1 IU/ml. Comparing our results with an earlier study by Stolz, Zwarte & Michel (1975, British Journal of Venereal Diseases 51, 257–64), the level of resistance to penicillin among non-PPNG has not significantly increased in The Netherlands since 1972.
The prevalence of isolates showing relative resistance towards tetracycline and thiamphenicol (MIC 2–4 mg/l) decreased from approximately 20% in 1983/84 to approximately 10% in 1985/86, coinciding with a drop in the prevalence of Pro– isolates. All strains were susceptible to cefuroxime and spectinomycin and highly susceptible to cefotaxime and riprofloxacin.
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