Journal of Antimicrobial Chemotherapy (1988) 21, 711-720
© 1988 The British Society for Antimicrobial Chemotherapy
research-article |
In-vitro microbiological activities of DuP 105 and DuP 721, novel synthetic oxazolidinones
Department of Medical Microbiology, The Royal Free Hospital Medical School Pond Street, Hampstead, London NW3 2QG, UK
Received 23 December 1987; accepted 15 February 1988
DuP 105 and 721, synthetic antibiotics belonging to a totally novel chemical class (oxazolidinones), have been found to be active in vitro against a wide range of Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus. DuP 721 had geometric mean MICs ranging from 1·1 to 16 mg/l against 167 strains of Staph. aureus, Staph. epidermidis, Staph. saprophyticus, streptococci of Groups A, B and D and diphtheroids. DuP 105 was between 1·5 and eight-fold less active. Bacteroides fragilis strains were also susceptible to the DuP compounds (mean MICs being 8·3 and 14·9 mg/l for DuP 721 and 105, respectively), but other Gram-negative species and yeasts were not inhibited' by concentrations in excess of 100 mg/l. Both compounds had a predominantly bacteriostatic action. No primary resistance was found, and the incidence of resistant variants in 105 strains tested was less than 1 per 103 bacteria.