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Journal of Antimicrobial Chemotherapy (1987) 20, 913-918
© 1987 The British Society for Antimicrobial Chemotherapy

research-article

Absence of disulfiram-type reactions to single and multiple doses of cefonicid: a placebo-controlled study

F.G. McMabon, J.R. Ryan, A.K. Jain, W. LaCorte and F. Ginzler

Tulane University School of Medicine and The Clinical Research Center 147 South Liberty Street, New Orleans, LA 70112, U.S.A.

accepted 22 July 1987

Disulfiram-type reactions after ingestion of alcohol have been reported in patients treated with a number of cephalosporin antibiotics; predominantly with agents containing the methythiotetrazole side chain, although other similar configurations have also been implicated. Since cefonicid has a sulphonic acid thiotetrazole substitution, we investigated the possibility of a cefonicid-ethanol interaction in 15 healthy volunteers. During the first two crossover phases of the study, single 1 g doses of cefonicid followed by ethanol challenges were compared to placebo followed by ethanol challenges. In the third phase, all volunteers received three consecutive 1 g doses of cefonicid given at 24 h intervals followed by an ethanol challenge. At no time did any of the subjects experience a disulfiram-type reaction, and their blood aldehyde concentrations did not increase throughout the study.


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