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Journal of Antimicrobial Chemotherapy (1987) 20, 883-885
© 1987 The British Society for Antimicrobial Chemotherapy

research-article

Failure of post-bacteraemia delayed antibiotic prophylaxis of experimental rabbit endocarditis

Jacqueline James, T.W. MacFarlanea, D.A. McGowan and D. MacKenziea

Department of Oral Surgery, Glasgow Dental Hospital and School 378 Sauchiehall Street, Glasgow G2 3JZ, U.K. aDepartment of Oral Microbiology Unit, Glasgow Dental Hospital and School 378 Sauchiehall Street, Glasgow G2 3JZ, U.K.

accepted 11 July 1987

Twenty-one rabbits had a cannula placed in the left ventricle and 48 h later 1 ml of a culture ofStreptococcus sanguis NCTC 7864 was injected into an ear vein. Six hours later, 400 mg/kg of amoxycillin was administered intramuscularly to 17 animals, the others acting as non-antibiotic treated controls. Two of the 17 rabbits died during the experimental period, and the cannula was incorrectly placed in another two. Five of the remaining 13 animals developed endocarditis. All controls developed endocarditis. Amoxycillin administered 6 h after an induced bacteraemia failed to prevent endocarditis in five (38%) of 13 rabbits.


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I. T. Carmona, P. Diz Dios, and C. Scully
Efficacy of Antibiotic Prophylactic Regimens for the Prevention of Bacterial Endocarditis of Oral Origin
Journal of Dental Research, December 1, 2007; 86(12): 1142 - 1159.
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