Journal of Antimicrobial Chemotherapy (1987) 20, 631-638
© 1987 The British Society for Antimicrobial Chemotherapy
research-article |
Induction of the SOS response by new 4-quinolones
Department of Microbiology, Hospital Ramon y Cajal Carretera de Colmenar Km 9.100, 28034 Madrid, Spain
accepted 19 June 1987
The 4-quinolones ciprofloxacin, difloxacin, enoxacin, norfloxacin, ofloxacin, and nalidixic acid were found to induce the SOS response in qualitative and quantitative tests on Escherichia coli K12 containing the sfiA::lacZ gene fusion. Maximum induction of the SOS-response was observed with the quinolone concentrations that produced the most killing. There was also a modest increase in the rate of mutation in the lactose and galactose operons in a GalE– background, provided there was a functioning SOS system.
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