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Journal of Antimicrobial Chemotherapy (1987) 20, 513-517
© 1987 The British Society for Antimicrobial Chemotherapy

research-article

LY146032: activity and resistance development in vitro

R. Peter Mouton and Sophie L. T. M. Mulders

Department of Medical Microbiology, University Hospital Leiden P.O. Box 9600, 2300 RC Leiden, The Netherlands

accepted 27 April 1987

LY 146032, a new lipopeptide antibiotic, was compared with vancomycin, teicoplanin, cefamandole and ciprofloxacin, against 107 clinical isolates comprising methicillin-susceptible and methicillin-resistant Staphylococcus spp., Streptococcus faecalis and Corynebacterium spp. All staphylococci were susceptible to all agents, except that some of the methicillin-resistant strains were resistant to cefamandole. Only LY 146032 and ciprofloxacin were bactericidal to Str. faecalis. Development of resistance was studied by serial transfers of ten selected strains. A stable ≥ eightfold increase of the MIC over the breakpoint was found to develop to a variable extent against all agents tested. Simultaneous development of resistance to any of the other antibiotics was registered in 11/200 tests.


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