Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Kettner, M.
Right arrow Articles by Langsádl, L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kettner, M.
Right arrow Articles by Langsádl, L.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Journal of Antimicrobial Chemotherapy (1987) 20, 383-387
© 1987 The British Society for Antimicrobial Chemotherapy

research-article

Aminoglycoside resistance patterns in clinical isolates of Enterobacteriaceae from Czechoslovakia

Milan Kettner, Jana Navarová and León Langsádla

Institute of Experimental Pharmacology, Centre for Physiological Sciences Slovak Academy of Sciences aNational Institute of Health Bratislava, Czechoslovakia

Received 28 February 1987;

Corresponding author: Dr Milan Kettner, Institute of Experimental Pharmacology, Centre for Physiological Sciences, Slovak Academy of Sciences, 842 16 Bratislava, Czechoslovakia.

Multi-resistant Enterobacteriaceae isolate mainly from urine specimens from patients at the Department of Urology, Kramáre Hospital, Bratislava, were characterized for resistance phenotype, Seventeen gentamicin-resistant isolates were further studied for the presence of aminoglycoside-modifying enzymes. Five enzymes were detected: AAC(2'), AAC(3)-II, AAC non-characterized, ANT(2'') and APH(3')-I. The substrate range of these enzymes was found to correlate with the resistance phenotype in most isolates, In our collection the AAC(3)-II enzyme that inactivates gentamicin, sisomicin, tobramycin and netilmicin was predominant. Predominance of this type of modifying enzyme has been observed also in resistant Gram-negative strains in Belgium, The Netherlands and Chile, in contrast to the United States, Federal Republic of Germany, Switzerland, Greece and Turkey, where ANT(2'')has been the most common enzyme.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.