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Journal of Antimicrobial Chemotherapy (1987) 20, 77-83
© 1987 The British Society for Antimicrobial Chemotherapy

research-article

Comparative efficacies of ciprofloxacin, ampicillin and chloramphenicol in treatment of experimental Haemophilus influenzae pneumonia

Bernd Kemmerich, Klaus Bornera and James E. Pennington*

Department of Medicine, Brigham and Women's Hospital and Harvard Medical School Boston, Massachusetts 02115, U.S.A. aInstitute for Clinical Chemistry and Biochemistry, Free University Berlin Berlin, West Germany

accepted 19 February 1987

*Corresponding author

An experimental murine model of bacteraemic Haemophilus influenzae pneumonia was used to evaluate the therapeutic efficacy of ciprofloxacin, as compared with ampicillin and chloramphenicol. An ampicillin-sensitive (AS) and an ampicillin-resistant (AR) challenge strain were employed. Ciprofloxacin treatment produced intrapulmonary killing of H.influenzae which was superior to that achieved with ampicillin (P <0.001, both strains) and chloramphenicol (P< 0.001, strain AS; P<0.005, strain AR). Likewise, survival from strain AS pneumonia was 61% in the ciprofloxacin-treated animals, as compared with 43% for the chloramphenicol-treated, and 22% for the ampicillin-treated groups. We conclude that ciprofloxacin may be an effective agent in treating pneumonia caused by either ampicillin-sensitive or ampicillin-resistant strains of H.influenzae.


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