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Journal of Antimicrobial Chemotherapy (1987) 20, 57-60
© 1987 The British Society for Antimicrobial Chemotherapy


research-article

Influence of stored aqueous ceftriaxone solutions on colony formation by neutrophil and macrophage precursor cells

M. Kisslinga, P. Kellerb and C. Nissenc

aPharma Clinical Research, F.Hoffman-La Roche & Co., Ltd. CH-4002 Basle, Switzerland bBiological-Pharmaceutical Research Department, F.Hoffmann-La Roche & Co., Ltd CH-4002 Basle, Switzerland cDepartment of Haematology of the University Clinic of Basle CH-4031 Basle, Switzerland

accepted 12 January 1987


Aqueous solutions of ceftriaxone in concentrations similar to those achieved in man and stored at temperatures of 4°C, 22°C and 37°C for up to four weeks were tested in methylcellulose cultures of normal bone marrow from ten donors.

No significant differences were detected between the colony formation by neutrophil and macrophage precursors in control cultures and in cultures containing stored ceftriaxone.

It is concluded that aqueous ceftriaxone solutions stored for up to four weeks at temperatures up to 37°C are not altered to such an extent that they adversely affect colony formation by bone marrow progenitor cells from healthy donors.


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