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Journal of Antimicrobial Chemotherapy (1986) 18, 199-201
© 1986 The British Society for Antimicrobial Chemotherapy

research-article

Pefloxacin concentrations in human aqueous humour and lens

A. Salvanet, A Fisch*, C. Lafaix*, G Montay{dagger}, P. Dubayle, F. Forestier and G. Harocbe*

Service d'Ophtalmologie, Centre hospitalier Villeneuve St Georges F94190 *Service des Maladies infectieuses, Centre hospitalier Villeneuve St Georges F94190 {dagger}Centre de Recherches, Laboratories Roger Bellon Alfortville F94190, France

accepted 3 March 1986

In 20 patients undergoing cataract extraction, we measured pefloxacin concentrations in the eye. After a 1 h infusion of pefloxacin 400 mg iv, the mean pefloxacin concentrations 2, 6, 12 and 24 h post-infusion were 0.75, 1.45, 1.04 and 0.86 mg/l, respectively, The simultaneous mean pefloxacin concentrations in the lens were 0.09, 0.20, 0.26 and 0.43 mg/1, respectively. The adequate penetration of pefloxacin into uninfected aqueous humour and lens suggests that this antibiotic may be effective in the treatment of certain bacterial endophthalmic infections.


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