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Journal of Antimicrobial Chemotherapy (1986) 17, 433-439
© 1986 The British Society for Antimicrobial Chemotherapy

research-article

Bactericidal and bacteriolytic activities of carumonam and its effect on bacterial morphology

Masafumi Nakao, Masahiro Kondo and Akira Imada

Central Research Division, Takeda Chemical Industries, Ltd. Osaka 532, Japan

accepted 13 September 1985

The in-vitro bactericidal and bacteriolytic activities and the effect on bacterial morphology of carumonam, a new N-sulfonated monocyclic ß-lactam antibiotic, against aerobic Gram-negative bacilli were compared with those of aztreonam. Both antibiotics, at their minimal inhibitory concentration (MIC) levels, were strongly bactericidal against species of Enterobacteriaceae, but weakly bactericidal against Pseudomonas aeruginosa. Their bactericidal activity was not increased by increasing the antibiotic concentration above the MICs. In contast to this potent bactericidal activity, the bacteriolytic activity of carumonam and aztreonam was low and limited to enteric bacterial species like Escherichia coli. Filamentation was the major morphological change of Gram-negative bacilli after exposure to carumonam and aztreonam. E. coli and Serratia marcescens, but not P. aeruginosa, were converted to ghosts after prolonged incubation with carumonam.


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