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Journal of Antimicrobial Chemotherapy (1985) 16, 527-530
© 1985 The British Society for Antimicrobial Chemotherapy


other

In-vitro activity of ciprofloxacin against clinical isolates of mycobacteria resistant to antimycobacterial drugs

E. Marinis* and N. J. Legakis{dagger},

*Microniological Laboratory, Chest Hospital of Athens ‘Sotiria’, Athens {dagger}Department of Microbiology, Medical School, University of Athens Athens, Greece

accepted 24 April 1985


Correspondence to: N. J. Legakis, Assoc. Prof., Department of Microbiology, Medical School, Athens 10010, P.O. Box 8540, Greece

The activity of ciprofioxacin against 42 clinical isolates of mycobacteria was studied in vitro by the 1% standard proportion method on Lowenstein-Jensen medium.

Ciprofloxacin was found active against all strains of Mycobacterium tuberculosis sensitive to streptomycin, isoniazid, ethambutol and rifampicin. The MIC of ciprofloxacin was 3·2 mg/l. This concentration of ciprofloxacin was sufficient to inhibit almost all strains showing intermediate sensitivity or resistance to one or more of the above agents. The same phenomenon was also observed with the atypical isolates.


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