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Journal of Antimicrobial Chemotherapy (1985) 16, 491-498
© 1985 The British Society for Antimicrobial Chemotherapy

research-article

Pharmacokinetics of clavulanic acid, given in combination with amoxycillin, in volunteers

I. Nilsson-Ehle*, H. Fellner, S.-Å. Hedström, P. Nilsson-Ehle and J. Sjövall

Departments of Infectious Diseases and Clinical Chemistry, University of Lund Sweden and ASTRA Läkemedel AB, Södertälje, Sweden

accepted 17 April 1985

*Correspondence to: I. Nilsson-Ehle, Department of Infectious Diseases, University of Lund, 221 85 Lund, Sweden

To study the absorption and disposition of clavulanic acid, ten healthy men received one intravenous and one oral dose of 125 mg clavulanic acid in combination with amoxycillin. Serum and urine concentrations were measured with high-performance liquid chromatography. The mean terminal half-lives in serum were 0·97 and 0·94 h, respectively. Total serum clearance was 248 ± 55 ml/min x 1·73 m2 Renal clearance was 108 ± 20 and 115 ± 18 ml/min x 1·73 m2 after intravenous and peroral administration. Urinary recovery over 12 h was 49· ± 8·7% of the intravenous and 35·7 ± 13·0% of the oral dose. The bioavailability of the oral dose averaged 60· ± 23·1% but varied considerably (range 31·4–98·8%), indicating very variable absorption from the gastrointestinal tract.


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