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Journal of Antimicrobial Chemotherapy (1983) 12, 475-480
© 1983 The British Society for Antimicrobial Chemotherapy

research-article

Serum bactericidal activity of cefoperazone and ceftazidime at increasing dosages against Pseudomonas aeruginosa

Y. Van Laethem, H. Lagast, M. Husson and J. Klastersky

Service de Médecine et Laboratoire d'Investigation Clinique H. J. Tagnon, Institut JulesBordet, Centre de Tumeurs de l'Université Libre de Bruxelles, I rue Héger Bordet, 1000 Bruxelles Belgium

accepted 1 June 1983

Serum bactericidal activity (SBA)greater double equals1:8 correlates with the clinical effectiveness of antibiotics. Ten healthy young volunteers received iv on separate days cefoperazone 1, 2, or 3 g and ceftazidime 1, 2, or 3 g. The serum levels 1 and 6 h after the administration of cefoperazone 1, 2 and 3 g were respectively 52 and 7 mg/1, 122 and 13 mg/l, 190 and 22 mg/l. The serum levels of ceftazidime 1, 2 and 3 g, after 1 h and 6 h were 28 and 8, 56 and 9, 78 and 13 mg/l. The SBA was determined against seven strains of Pseudomonas aeruginosa with MBC of 1.6–12.5 mg/l of cefoperazone and 0.8–6.2 mg/l of ceftazidime. Increased dosage of cefoperazone and ceftazidime led to a significant increase in the SBA's >1:8 at 1 h(P<0.01).

In sera obtained 1 h and 6 h after the injection of the antibiotics, 97% and 51% of the strains were inhibited by ceftazidime 2 g, while 1 g was inhibitory on 84% (1 h) and 8% (6 h) of the strains. Ceftazidime 1 g produced SBA's> 1:8 significantly more often than did cefoperazone 3 g (P<0.01) at 1 h. The rate of killing with all ceftazidime regimens was similar and slightly higher than that of any cefoperazone regimen.

Ceftazidime seems more effective than cefoperazone against Ps. aeruginosa; however, increased MBC values were observed during killing curves studies with both drugs.


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