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Journal of Antimicrobial Chemotherapy (1975) 1, 403-409
© 1975 The British Society for Antimicrobial Chemotherapy

other

Combined activity of clindamycin and gentamicin on Bacteroides fragilis and other bacteria

O. A. Okubadejo and Janet Allen

Public Health Laboratory St Mary's General Hospital, Portsmouth, England

accepted 24 June 1975

In vitro experiments showed that strains of Bacillus fragilis, Staphylococcus aureus, Escherlchia coli, Proteus, mirabiis, and anaerobic Gram-positive cocci were killed by combinations of clindarnycin and the arninoglycosides gentamicin, or kanamycin with no evidence of antibiotic antagonism. The combination of clindaxnycin and gentamicin was superior to that of clindamycin and kanamycin especially for Pseudomonas aeruginosa, Staph. aureus and B. fragilis. Clindamycin and gentamicin acted synergistically on cultures of B.fragilis, indicating that the combination might be useful in the treatment of serious infections with a mixture of B. fragilis and other bacteria, and in B. fragills endocarditis.


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