Skip Navigation

This Article
Right arrow Extract Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Piddock, L. J. V.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Piddock, L. J. V.

Journal of Antimicrobial Chemotherapy (2002) 49, 215
© 2002 The British Society for Antimicrobial Chemotherapy

Correspondence

Laura J. V. Piddock,*

Antimicrobial Agents Research Group, Division of Immunity and Infection, The Medical School, Edgbaston, Birmingham B15 2TT, UK

Sir,

A recent article by Thomas et al. in the Journal (2001; 48: 553–555) describes a clinical isolate of Pseudomonas aeruginosa that was selected after fluoroquinolone therapy and combined mutation in a gene encoding DNA gyrase and overexpression of an efflux pump. We should like to bring to the attention of your readership that a similar posttherapy isolate of P. aeruginosa was described previously.1–3 This post-therapy isolate (G49) was selected during therapy in 1986 with enoxacin and was multiply resistant to several unrelated classes of antibiotic, includ-ing fluoroquinolones, ß-lactams, chloramphenicol and tetracycline. G49 lacked OprF and had an altered lipopolysaccharide profile and a point mutation in gyrA conferring a substitution of threonine 83 to isoleucine.2 However, these changes did not fully account for the multiple antibiotic resistance phenotype of G49. Subsequent analyses showed that G49 also overexpressed two efflux pumps, MexAB-OprM and MexCD-OprN.3

Notes

* Tel: +44-121-414-6966; Fax: +44-121-414-3454; E-mail: l.j.v.piddock{at}bham.ac.uk Back

References

1 . Piddock, L. J. V., Hall, M. C., Bellido, F., Bains, M. & Hancock, R. E. W. (1992). A pleiotropic, post-therapy enoxacin-resistant mutant of Pseudomonas aeruginosa. Antimicrobial Agents and Chemotherapy 36, 1057–61. [Abstract/Free Full Text]

2 . Pumbwe, L., Everett, M. J., Hancock, R. E. W. & Piddock, L. J. V. (1996). Role of gyrA mutation and loss of OprF in the multiple antibiotic resistance (MAR) phenotype of Pseudomonas aeruginosa G49. FEMS Microbiology Letters 143, 25–8.

3 . Pumbwe, L. & Piddock, L. J. V. (2000). Two efflux systems expressed simultaneously in multiply antibiotic resistant Pseudomonas aeruginosa. Antimicrobial Agents and Chemotherapy 44, 2861–4. [Abstract/Free Full Text]




This article has been cited by other articles:


Home page
 The Annals of PharmacotherapyHome page
J. P Gettig, C. W Crank, and A. H Philbrick
Faropenem Medoxomil
Ann. Pharmacother., January 1, 2008; 42(1): 80 - 90.
[Abstract] [Full Text] [PDF]

This Article
Right arrow Extract Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Piddock, L. J. V.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Piddock, L. J. V.