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JAC Advance Access originally published online on October 21, 2009
Journal of Antimicrobial Chemotherapy 2009 64(6):1336-1338; doi:10.1093/jac/dkp375
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© The Author 2009. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Research letters

In vitro activity of the new quinolone derivative RD-3 against clinical isolates of Mycoplasma pneumoniae and Mycoplasma hominis

Shilpakala Sainath Rao* and Malathi Raghunathan

Department of Genetics, Dr ALMPGIBMS, University of Madras, Taramani Campus, Chennai 600113, India

* Corresponding author. Tel: +91-044-24925317; Fax: +91-044-24926709; E-mail: shilpa_ibms@yahoo.com

Keywords: MICs , MBCs , fluoroquinolones

The first 10% of the full text of this article appears below.

Sir,

RD-3 is a new investigational quinolone derivative with the formula bis(4,9,9a,10-tetrahydro-9-phenyl-3bH-pyrrolizino-[1, 2-b]quinolin-7-)methane 12, synthesized by the Department of Organic Chemistry, University of Madras, Chennai, India (Figure 1). This drug has shown significant activity against Gram-positive and Gram-negative organisms.1


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  		Figure 1. Chemical structure of RD-3.

 
Mycoplasma pneumoniae is a significant cause of upper and lower respiratory tract infections in persons of all age groups.2 In some cases, these organisms can cause severe, systemic disease, especially in the setting of . . . [Full Text of this Article]


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