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JAC Advance Access originally published online on June 30, 2009
Journal of Antimicrobial Chemotherapy 2009 64(3):657-658; doi:10.1093/jac/dkp229
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© The Author 2009. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Research letters

Controlling for false positives: interpreting MBL Etest and MBL combined disc test for the detection of metallo-β-lactamases

Csilla Ratkai1, Sandra Quinteira2,3, Filipa Grosso2, Nuno Monteiro4,5, Elisabeth Nagy1 and Luísa Peixe2,*

1 Institute of Clinical Microbiology, University of Szeged, Szeged, Hungary 2 REQUIMTE, Laboratório de Microbiologia, Faculdade de Farmácia, Universidade do Porto, Porto, Portugal 3 Centro de Investigação em Tecnologias da Saúde/IPSN (CESPU), VN Famalicão, Portugal 4 CEBIMED, Faculdade de Ciências da Saúde, Universidade Fernando Pessoa, Porto, Portugal 5 CIIMAR, Centre of Environmental and Marine Research, Laboratório de Ecologia, Porto, Portugal

* Corresponding author. Tel: +351-222078946; Fax: +351-222003977; E-mail: lpeixe@ff.up.pt

Keywords: carbapenem resistance , Pseudomonas aeruginosa , false-positive detection

The first 10% of the full text of this article appears below.

Sir,

Metallo-β-lactamases (MBLs) are enzymes with versatile hydrolytic capabilities, namely the ability to hydrolyse all β-lactam antibiotics, with the exception of monobactams. Consequently, bacteria producing MBLs often cause infections that are difficult to treat due to the ineffectiveness of β-lactams. Often, the genes encoding MBLs are located on integrons that frequently harbour other resistance determinants and that may be associated with mobile genetic elements, thus increasing the likelihood of their dissemination. MBLs are particularly associated with Gram-negative pathogens, and their occurrence requires continuous monitoring due to their potential impact on patient management and the . . . [Full Text of this Article]


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