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JAC Advance Access originally published online on June 30, 2009
Journal of Antimicrobial Chemotherapy 2009 64(3):649-650; doi:10.1093/jac/dkp227
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© The Author 2009. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Research letters

Mupirocin resistance among staphylococci: trends in the southern region of Ireland

Susan O'Shea1, Lesley Cotter1, Sinead Creagh2, Sara Lydon1 and Brigid Lucey2,*

1 Department of Biological Sciences, Cork Institute of Technology, Rossa Avenue, Bishopstown, Cork, Ireland 2 Department of Microbiology, Cork University Hospital, Cork, Ireland

* Corresponding author. Tel: 00353-21-4922505; Fax: 00353-21-4920076; E-mail: brigid.lucey@cit.ie

Keywords: coagulase-negative , MRSA , ileS gene

The first 10% of the full text of this article appears below.

Sir,

Mupirocin is a topical antibiotic used particularly to eradicate methicillin-resistant Staphylococcus aureus (MRSA) carriage and to prevent infection. It is currently not mandatory in Ireland to screen patients for MRSA and decolonize them. Mupirocin-resistant strains are divided into two distinct groups: those with low-level mupirocin resistance (LMR); and those with high-level mupirocin resistance (HMR). LMR (MIC 8–256 mg/L) results from spontaneous point mutations in the chromosomally encoded ileS gene, which is stable and non-transferable.1 Strains with HMR (MIC > 512 mg/L) possess mupA encoding a second staphylococcal ileS, which is found on an extrachromosomal plasmid and is . . . [Full Text of this Article]


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