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JAC Advance Access published online on May 12, 2008
Journal of Antimicrobial Chemotherapy, doi:10.1093/jac/dkn202
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© The Author 2008. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Research letter

Macrolide resistance among invasive Streptococcus pneumoniae in Slovenia

Tamara Kastrin1,*, Marija Gubina2, Metka Paragi1, Jana Kolman3, Milan Cizman4, Alenka Kraigher1, Helena Ribic5, Ewa Sadowy6 and Waleria Hryniewicz6

1 Department of Medical Microbiology, Institute of Public Health of the Republic of Slovenia, Grabloviceva 44, 1000 Ljubljana, Slovenia 2 School of Health Science, Higher Education Centre Novo mesto, Na Loko 2, 8000 Novo mesto, Slovenia 3 University Medical Centre Ljubljana, Infection Control Service, Japljeva 2, 1525 Ljubljana, Slovenia 4 Department of Infectious Diseases, University Medical Centre Ljubljana, Japljeva 2, 1525 Ljubljana, Slovenia 5 The Institute of Public Health Kranj, Gosposvetska 12, 4000 Kranj, Slovenia 6 National Medicines Institute, Chelmska 30/34, 00-725 Warsaw, Poland

* Corresponding author. Tel: +386-1-5205-708; Fax: +386-1-5205-704; E-mail: tamara.kastrin@ivz-rs.si

Key Words: pneumococci , erythromycin , serotype , erm(B) , mef(A)

The first 10% of the full text of this article appears below.

Sir,

The worldwide increase in antibiotic resistance of Streptococcus pneumoniae has become a serious problem in recent years, including the increasing resistance to macrolides. In Slovenia, the epidemiological situation of invasive diseases, caused by S. pneumoniae, has been constantly monitored since 1993.1,2

The objectives of this study were to characterize the macrolide-resistant clinical isolates of invasive S. pneumoniae in Slovenia and to investigate the genetic basis of macrolide resistance.

A total of 1448 invasive isolates of S. pneumoniae, . . . [Full Text of this Article]


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