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JAC Advance Access originally published online on November 12, 2003
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Journal of Antimicrobial Chemotherapy (2003) 52, 890-892
© 2003 The British Society for Antimicrobial Chemotherapy

Leading Article

Preventing HIV-1 sexual transmission—not sexy enough science, or no benefit to the bottom line?

John P. Moore1,* and Robin J. Shattock2

1 Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, USA; 2 Department of Cellular and Molecular Medicine, Infectious Diseases, St. George’s Hospital Medical School, London, UK

Keywords: HIV, microbicides, transmission

The first 150 words of the full text of this article appear below.

In the continued, and likely to be prolonged, absence of an effective vaccine, the scientific community needs to find an alternative way to prevent the sexual transmission of human immunodeficiency virus type 1 (HIV-1). The global HIV-1 epidemic is fuelled by heterosexual transmission, which is how about 80% of the 40 million people now infected acquired this lethal virus.1 Most (~95%) new infections now occur in the developing world, almost half among women.1 Although HIV-1 infection is not particularly easy to acquire sexually, the lengthy duration of asymptomatic infection, the high frequency with which at least some people have sexual intercourse, and various exacerbating circumstances, all conspire to render HIV-1 readily transmissible in the long run. What can be done about this? Education and condom distribution play important roles in reducing transmission, but sexual behaviour is notoriously difficult to modify, particularly among young people, and there are often cultural . . . [Full Text of this Article]


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