JAC Advance Access originally published online on June 12, 2003
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Journal of Antimicrobial Chemotherapy (2003) 52, 1
© 2003 The British Society for Antimicrobial Chemotherapy
Editorial |
Synergy, antagonism, and what the chequerboard puts between them
Department of Molecular & Cell Biology, University of Aberdeen, Institute of Medical Sciences, Aberdeen AB25 2ZD, UK
Keywords: synergy, antagonism, antimicrobial combinations, FIC index, chequerboard
| The first 10% of the full text of this article appears below. |
The study of interactive effects between molecules has a long history. For antimicrobial drugs, the use of paired and triple combinations of inhibitory agents in the clinic often begins with tests in vitro that show positive interactions inhibiting the growth of target microorganisms. There are many models for experimental designs to measure such combination effects. One of the best known
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