Skip Navigation


JAC Advance Access originally published online on April 25, 2003
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
51/6/1323    most recent
dkg255v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (17)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Smith, H. J.
Right arrow Articles by Zhanel, G. G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Smith, H. J.
Right arrow Articles by Zhanel, G. G.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?


Journal of Antimicrobial Chemotherapy (2003) 51, 1323-1325
© 2003 The British Society for Antimicrobial Chemotherapy

Leading Article

Stretching the mutant prevention concentration (MPC) beyond its limits

Heather J. Smith1,*, Kimberly A. Nichol1,2, Daryl J. Hoban1,2 and George G. Zhanel1,3

1 Department of Medical Microbiology, Faculty of Medicine, University of Manitoba, Manitoba; Departments of 2 Clinical Microbiology and 3 Medicine, Health Sciences Centre, Winnipeg, Manitoba, Canada

Keywords: mutant prevention concentration, resistance mechanisms

The first 10% of the full text of this article appears below.

Antibiotic resistance is increasingly recognized as a serious global problem. The mutant prevention concentration (MPC) is a novel concept1 that has been employed in the evaluation of an antibiotic’s ability to minimize or limit the development of resistant organisms.2 The MPC has been defined as the MIC of the least susceptible single-step mutant.1,2 By definition, cell growth in the presence of antibiotic concentrations greater than the MPC requires an organism to have developed two or more resistance-causing spontaneous chromosomal point mutations.1,2

The MPC concept may . . . [Full Text of this Article]


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Antimicrob. Agents Chemother.Home page
A.-S. Kesteman, A. A. Ferran, A. Perrin-Guyomard, M. Laurentie, P. Sanders, P.-L. Toutain, and A. Bousquet-Melou
Influence of Inoculum Size and Marbofloxacin Plasma Exposure on the Amplification of Resistant Subpopulations of Klebsiella pneumoniae in a Rat Lung Infection Model
Antimicrob. Agents Chemother., November 1, 2009; 53(11): 4740 - 4748.
[Abstract] [Full Text] [PDF]

Home page
 Antimicrob. Agents Chemother.Home page
E. D. Hermsen, L. B. Hovde, G. N. Konstantinides, and J. C. Rotschafer
Mutant Prevention Concentrations of ABT-492, Levofloxacin, Moxifloxacin, and Gatifloxacin against Three Common Respiratory Pathogens
Antimicrob. Agents Chemother., April 1, 2005; 49(4): 1633 - 1635.
[Abstract] [Full Text] [PDF]

Home page
 The Annals of PharmacotherapyHome page
B. J Epstein, J. G Gums, and K. Drlica
The Changing Face of Antibiotic Prescribing: The Mutant Selection Window
Ann. Pharmacother., October 1, 2004; 38(10): 1675 - 1682.
[Abstract] [Full Text] [PDF]

Home page
 J Antimicrob ChemotherHome page
X. Zhao
Clarification of MPC and the mutant selection window concept
J. Antimicrob. Chemother., October 1, 2003; 52(4): 731 - 731.
[Full Text] [PDF]

Home page
 J Antimicrob ChemotherHome page
D. M. Livermore
Overstretching the mutant prevention concentration
J. Antimicrob. Chemother., October 1, 2003; 52(4): 732 - 732.
[Full Text] [PDF]

Home page
 J Antimicrob ChemotherHome page
H. J. Smith, D. J. Hoban, and G. G. Zhanel
Reply
J. Antimicrob. Chemother., October 1, 2003; 52(4): 732 - 733.
[Full Text] [PDF]