Journal of Antimicrobial Chemotherapy (2002) 49, 709-712
© 2002 The British Society for Antimicrobial Chemotherapy
Leading article |
Role of newer fluoroquinolones in lower respiratory tract infections
Department of Chest and Infectious Diseases, Chest Hospital Heckeshorn, Central Clinic Emil von Behring, Zum Heckeshorn 33, 14109 Berlin, Germany
The impact of respiratory infections on inviduals in society is important and is growing as the population ages. Lower respiratory tract infections in particular are major causes of morbidity and mortality. These infections include acute exacerbation of chronic bronchitis (AECB) and community-acquired pneumonia. Of the two conditions, AECB is more prevalent, occurring in 46% of the population over 65 years old in Germany, with an average of 2.4 acute exacerb- ations per patient each year. In the UK, chronic bronchitis causes 5% of deaths and is responsible for 28 million lost working days per year.
Community-acquired respiratory tract infections (RTIs) may be caused by Gram-positive organisms (predominantly Streptococcus pneumoniae), Gram-negative organisms (Haemophilus influenzae and Moraxella catarrhalis) and atypical bacteria (e.g. Chlamydia pneumoniae, Legionella pneumophila and Mycoplasma pneumoniae). In community-acquired pneumonia (CAP) pathogens, penicillin resistance
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