Dormant tubercle bacilli: the key to more effective TB chemotherapy?

doi:10.1093/jac/47.1.117

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Journal of Antimicrobial Chemotherapy (2001) 47, 117-118
© 2001 The British Society for Antimicrobial Chemotherapy

Correspondence

Dormant tubercle bacilli: the key to more effective TB chemotherapy?

T. Dick

Mycobacterium Laboratory, Institute of Molecular & Cell Biology, 30 Medical Drive, Singapore 117609, Singapore

Sir,

A key problem in tuberculosis control is the persistence ofMycobacterium tuberculosis despite prolonged chemotherapy: treatmentfor 6–12 months is required to cure acute disease or eliminatelatent infection. Why does it take so long to eradicate thebacilli once they reside within the human host? Developmentof physiological (as opposed to genetic) drug resistance couldplay a role. Mycobacteria are obligate aerobes. However, ithas been known for years that tubercle bacilli encounter hypoxicenvironments in acute disease as . . . [Full Text of this Article]

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