Journal of Antimicrobial Chemotherapy (2000) 45, 267-270
© 2000 The British Society for Antimicrobial Chemotherapy
Leading article |
Management of intravascular catheter-related infections
Section of Infection Control, Department of Internal Medicine Specialties, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston TX 77030, USA
Despite the availability of novel and highly effective broad-spectrum antimicrobial chemotherapeutic agents, intravascular catheter-related bloodstream infections (CRBSI) continue to be associated with an attributable mortality rate of 25% in critically ill patients.1,2 Because of their complexity, the management of such infections is often a challenge to the physician caring for seriously ill hospitalized patients. In approaching a patient with a central venous catheter (CVC) and fever or a positive blood culture the physician should be able to answer the following questions related to management: (i) Is the positive blood culture related to contamination from skin microorganisms, colonization of the internal surface of the catheter or bloodstream infection? (ii) What is the source of the bloodstream infection? The catheter or elsewhere? (iii) Should the catheter be removed? (iv) What is the choice and duration of antimicrobial therapy?
Colonization versus infection
Febrile patients with a CVC are often managed by drawing blood cultures simultaneously through
The source of bacteraemia
Catheter removal
Antimicrobial therapy
Notes
References
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  C Marshall, J Samuel, A Galloway, and S Pedler Mycobacterium mucogenicum from the Hickman line of an immunocompromised patient J. Clin. Pathol., January 1, 2008; 61(1): 140 - 141. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Segarra-Newnham and E. M Martin-Cooper Antibiotic Lock Technique: A Review of the Literature Ann. Pharmacother., February 1, 2005; 39(2): 311 - 318. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. P. Bachmann, K. VandeWalle, G. Ramage, T. F. Patterson, B. L. Wickes, J. R. Graybill, and J. L. Lopez-Ribot In Vitro Activity of Caspofungin against Candida albicans Biofilms Antimicrob. Agents Chemother., November 1, 2002; 46(11): 3591 - 3596. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. R. Ashbee and E. G. V. Evans Immunology of Diseases Associated with Malassezia Species Clin. Microbiol. Rev., January 1, 2002; 15(1): 21 - 57. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Berrington and F. K. Gould Use of antibiotic locks to treat colonized central venous catheters J. Antimicrob. Chemother., November 1, 2001; 48(5): 597 - 603. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Managing bloodstream infections associated with intravascular catheters DTB, October 1, 2001; 39(10): 75 - 80. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. R. Donowitz, D. G. Maki, C. J. Crnich, P. G. Pappas, and K. V.I. Rolston Infections in the Neutropenic Patient-- New Views of an Old Problem Hematology, January 1, 2001; 2001(1): 113 - 139. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Worthington, P. Lambert, and T. Elliott A novel serological test for the laboratory diagnosis of central venous catheter-associated sepsis J. Antimicrob. Chemother., September 1, 2000; 46(3): 516 - 516. [Full Text] [PDF]
|
|