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Journal of Antimicrobial Chemotherapy (2000) 45, 137-138
© 2000 The British Society for Antimicrobial Chemotherapy

Leading article

Is interruption of HIV therapy always harmful?

M. Youle

Royal Free Centre for HIV Medicine, Royal Free Hospital, Pond Street, London NW3 2QG, UK

Human immunodeficiency virus (HIV) infection is associated with progressive immune damage leading to AIDS. Since the advent of combination antiretroviral chemotherapy clear morbidity and mortality benefits have been shown.1 Reversal of clinical disease and improvement in health status has resulted in a massive change in the epidemiology of HIV and AIDS2 and is seen as a remarkable therapeutic success story. However, these benefits have been accrued in spite of increasing evidence of long-term drug toxicity3 and with difficulty in compliance in taking this therapy.4

In other disease areas, such as oncology, intermittent therapy has been utilized to deal successfully . . . [Full Text of this Article]

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