Journal of Antimicrobial Chemotherapy (1999) 44, 133-134
© 1999 The British Society for Antimicrobial Chemotherapy
Correspondence |
Emergence of mefA and mefE genes in beta-haemolytic streptococci and pneumococci in France
J Antimicrob Chemother 1999; 44: 133–134
Laboratoire de Microbiologie, Université Victor Segalen Bordeaux 2, 146 rue Léo Saignat, 33076 Bordeaux cedex, France
Sir,
Since the early 1990s, most developed countries have experienced a rapid and substantial
increase in erythromycin resistance among isolates of Streptococcus pyogenes and Streptococcus pneumoniae, probably related to the increased prescribing of this antibiotic or
its novel semisynthetic derivatives.
1 Until recently, the unique mechanism of macrolide
resistance recognized in streptococci was target modification by 23S rRNA methylases encoded
by erm genes, which convey cross-resistance to macrolides, lincosamides and the
streptogramin B compounds (MLS
B phenotype). With the increase of erythromycin resistance, a
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