Journal of Antimicrobial Chemotherapy (1999) 43, 171-176
© 1999 The British Society for Antimicrobial Chemotherapy
Leading article |
Occurrence and epidemiology of resistance to virginiamycin and streptogramins
a Departments of Medicine and Clinical Pathology, Section of Infectious Diseases, William Beaumont Hospital, Royal Oak, MI b Wayne State University School of Medicine, Detroit, MI, USA
Introduction
Non-human sources have been increasingly suspected as reservoirs for some
antibiotic-resistant bacteria. Antibiotics are used in animals both to treat infections and as growth
promoters. The potential role that antibiotic use in veterinary medicine and animal husbandry
plays in the transfer of antibiotic-resistant bacteria to humans is a controversial issue. There is
clear evidence that the increase in consumption of antibiotics by animals has been accompanied
by a similar rise in the number of antibiotic-resistant strains isolated.1,2,3,4,5
,6 It has been suspected that antibiotic
use in food animals has resulted in the novel resistance genes and multiresistant pathogens that
have emerged in these animals.7
,8,9
,10,11
,12,13
,14,15
,16,17
,18,19
,20 Dupont & Steele20
reported
that 45% of antimicrobial use in the USA was for animal feed
supplementation. Studies of salmonella,14 Escherichia
coli,12 enterococci6,7,8,9,10
,11,15
,16,17 and
campylobacter13
support the claim that novel resistance genes may be selected in the bacterial flora of animals as a
direct consequence of antibiotic
Streptogramin-resistant E. faecium in Europe
Streptogramin-resistant enterococci in the USA
Acknowledgments
Notes
References
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