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JAC Advance Access published online on May 20, 2008
Journal of Antimicrobial Chemotherapy, doi:10.1093/jac/dkn215
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© The Author 2008. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Original research

Combined therapy in treatment of murine infection by Fusarium solani

Mery Ruíz-Cendoya, Marçal Mariné and Josep Guarro*

Unitat de Microbiologia, Facultat de Medicina i Ciències de la Salut, Universitat Rovira i Virgili, Reus, Spain

Received 4 February 2008; returned 14 March 2008; revised 18 April 2008; accepted 25 April 2008

* Correspondence address. Unitat de Microbiologia, Facultat de Medicina, Universitat Rovira i Virgili, Carrer Sant Llorenç, 21, 43201 Reus, Spain. Tel: +34-977-759359; Fax: +34-977-759322; E-mail: josep.guarro{at}urv.cat

Objectives: We evaluated the efficacy of voriconazole, amphotericin B and micafungin alone and combined in a murine model of disseminated infection by Fusarium solani.

Methods: Immunosuppressed mice were treated with voriconazole at 60 mg/kg/day, amphotericin B at 3 mg/kg/day, micafungin at 10 mg/kg/day or combinations of these antifungal drugs. For survival studies, treatment began 1 day after infection and continued for 10 days. For tissue burden studies, animals were sacrificed on day 6 of the treatment and the fungal load in the kidneys and spleens was measured. The experiments were carried out using two different clinical strains of F. solani.

Results: Only the combination of voriconazole plus amphotericin B prolonged the survival of the mice versus the controls for the two strains tested. However, this combination only reduced tissue burden in the kidney and spleen of mice infected by one strain. The other treatments were clearly less effective.

Conclusions: Voriconazole plus amphotericin B may have a role in the treatment of fusariosis.

Key Words: voriconazole , amphotericin B , micafungin , murine model


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