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JAC Advance Access published online on April 25, 2008
Journal of Antimicrobial Chemotherapy, doi:10.1093/jac/dkn175
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© The Author 2008. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Leading article

Why are there different dynamics in the selection of drug resistance in HIV and hepatitis B and C viruses?

Vincent Soriano1,*, Alan S. Perelson2 and Fabien Zoulim3

1 Department of Infectious Diseases, Hospital Carlos III, Sinesio Delgado 10, 28029 Madrid, Spain 2 Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, New Mexico, USA 3 INSERM, U871, Université Lyon 1, Hospices Civils de Lyon, Lyon, France

* Corresponding author. Tel: +34-91-4532500; Fax: +34-91-7336614; E-mail: vsoriano{at}dragonet.es

The arrival of new antiviral drugs to treat chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infections has given rise to great expectations along with concerns regarding the selection of drug-resistant variants. Many lessons learnt from HIV therapeutics can be helpful for designing adequate treatment strategies against viral hepatitis, the avoidance of sequential weak monotherapies being one of them. Although HIV, HBV and HCV share many biological features, including very rapid viral dynamics, distinctive characteristics explain why the speed of selection of drug resistance differs substantially between these viruses, being faster for HCV than for HIV and slower for HBV.

Key Words: HBV , HCV , resistance mechanisms


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