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JAC Advance Access published online on February 26, 2007
Journal of Antimicrobial Chemotherapy, doi:10.1093/jac/dkl509
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© The Author 2007. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Review

Porins, efflux pumps and multidrug resistance in Acinetobacter baumannii

Jordi Vila*, Sara Martí and Javier Sánchez-Céspedes

Servei de Microbiologia, Centre de Diagnòstic Biomèdic, Hospital Clínic, IDIBAPS, Facultat de Medicina, Universitat de Barcelona, Barcelona, Spain

* Correspondence address. Servei de Microbiologia, Centre de Diagnòstic Biomèdic, Hospital Clinic, Villarroel 170, 08036 Barcelona, Spain. Tel: +34-93-2275522; Fax: +34-93-2279372; E-mail: jvila{at}ub.edu

Acinetobacter baumannii is an opportunistic pathogen, causing infections mainly in patients in intensive care units where the extensive use of antimicrobial agents can select for the emergence of multiresistant strains. In fact, since strains resistant to all antimicrobial agents have been reported, A. baumannii is considered the paradigm of multiresistant bacteria. Both acquired and intrinsic resistance can contribute to multiresistance. The ability to acquire multidrug resistance can be due to either the acquisition of genetic elements carrying multiple resistant determinants or mutations affecting the expression of porins and/or efflux pump(s), which can affect unrelated antimicrobial agents. Meanwhile, intrinsic resistance can be generated by the interplay of decreased permeability and constitutive expression of active efflux systems and it too can affect unrelated antimicrobial agents. This review is focused on the current knowledge of porins and efflux pump(s) in this microorganism.

Key Words: permeability , intrinsic resistance , A. baumannii


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