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Journal of Antimicrobial Chemotherapy (1981) 8, 337-342
© 1981 The British Society for Antimicrobial Chemotherapy

research-article

Antibacteroides and ß-lactamase inhibitory activities of moxalactam

Kwung P. Fu and Harold C. Neu*

Division of Infectious Diseases, Departments of Medicine and Pharmacology, College of Physicians and Surgeons, Columbia University New York, NY 10032, U.S.A.

accepted 10 June 1981

*Reprint requests to: Department of Medicine, 630 West 168 Street, New York, NY 10032, U.S.A.

The in-vitro activity of moxalactam against Bacteroides species was investigated and compared to those of other newer cephalosporins. Moxalactam was most active at 2 mg/l inhibiting 74% of the strains tested; whereas, only 20% were inhibited by cefoxitin and none were inhibited by cefotaxime, cefoperazone or ceftizoxime. The stability to ß-lactamase hydrolysis of moxalactam and its ß-lactamase inhibitory activity were compared to those of newer cephalosporins and penicillanic acid suiphone. Moxalactam and cefoxitin were not hydrolyzed by ß-lactamases produced by the Bacteroides tested. On weight basis, moxalactam was a more potent inhibitor than cefoxitin and penicillanic acid sulfone against Bact. fragills ß-lactamase. Cefotaxime was not an inhibitor of Bacteroides ß.-lactamases.


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