Skip Navigation


JAC Advance Access originally published online on August 25, 2009
Journal of Antimicrobial Chemotherapy 2009 64(5):929-937; doi:10.1093/jac/dkp302
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Supplementary Data
Right arrow All Versions of this Article:
64/5/929    most recent
dkp302v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Li, A. M. M. Y.
Right arrow Articles by Lipman, J.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Li, A. M. M. Y.
Right arrow Articles by Lipman, J.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2009. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Systematic review

A systematic review of antibiotic dosing regimens for septic patients receiving continuous renal replacement therapy: do current studies supply sufficient data?

A. M. M. Y. Li1,*, C. D. Gomersall1, G. Choi1, Q. Tian1, G. M. Joynt1 and J. Lipman2

1 Department of Anaesthesia & Intensive Care, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong 2 Burns Trauma Critical Care Research Centre, University of Queensland, Herston QLD 4029, Australia

Received 15 April 2009; returned 29 May 2009; revised 26 July 2009; accepted 27 July 2009

* Corresponding author. E-mail: alex_li{at}mac.com

Background: Drug dosing for septic patients with acute renal failure receiving continuous renal replacement therapy (CRRT) is complicated, and failure to correctly dose may result in either drug toxicity or treatment failure and development of antibiotic resistance. The aim of this study was to establish an ideal dataset that needs to be reported when presenting pharmacokinetic data for these patients and review current literature for completeness of this dataset.

Methods: An ideal dataset was established of the parameters that should be reported when calculating a drug dosing regimen from first principles. A Medline search was performed of relevant literature producing 64 citations from which completeness of the specified criteria was examined.

Results: None of the studies analysed presented the full dataset that we established as necessary. Of concern, basic pharmacokinetic parameters such as volume of distribution (Vd) and clearance (CL) were specified in only 79% and 81% of studies, respectively.

Conclusions: A large proportion of current studies do not report key information necessary to devise a rational dosing regimen for patients with acute renal failure receiving CRRT, and we hope this dataset will be a useful guide when reporting future pharmacokinetic data.

Keywords: antibiotics , drug dosing , pharmacokinetics , renal replacement therapy , sepsis


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.