Skip Navigation


JAC Advance Access originally published online on September 9, 2009
Journal of Antimicrobial Chemotherapy 2009 64(5):901-909; doi:10.1093/jac/dkp316
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
64/5/901    most recent
dkp316v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Maagaard, A.
Right arrow Articles by Kvale, D.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Maagaard, A.
Right arrow Articles by Kvale, D.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2009. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Reviews

Mitochondrial toxicity in HIV-infected patients both off and on antiretroviral treatment: a continuum or distinct underlying mechanisms?

Anne Maagaard1,2,3,* and Dag Kvale1,3

1 Ullevål Department of Infectious Diseases, Oslo University Hospital, Kirkeveien 166, 0407 Oslo, Norway 2 Ullevål Department of Microbiology, Oslo University Hospital, Kirkeveien 166, 0407 Oslo, Norway 3 Faculty of Medicine, University of Oslo, Oslo, Norway

* Corresponding author. Tel: +47-22-11-91-00; Fax: +47-22-11-91-81; E-mail: anne.maagaard{at}medisin.uio.no

Mitochondrial toxicity contributes to serious adverse effects observed in HIV-infected individuals treated with nucleoside reverse transcriptase inhibitors (NRTIs). However, similar mitochondrial abnormalities have recently been found even in treatment-naive patients, suggesting that chronic HIV per se could contribute to the toxicity observed in NRTI-exposed individuals. This review gives a current status of the field, with particular focus on recent observations suggesting that distinct mechanisms might cause such toxicity in both NRTI-exposed individuals and those naive to antiretroviral treatment.

Keywords: HIV-1 , mitochondria , DNA polymerase gamma , nucleoside reverse transcriptase inhibitors , persistent immune activation


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.