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JAC Advance Access originally published online on September 10, 2009
Journal of Antimicrobial Chemotherapy 2009 64(5):1111-1113; doi:10.1093/jac/dkp332
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© The Author 2009. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Original research

Has the publication of methicillin-resistant Staphylococcus aureus (MRSA) treatment guidelines increased the survival associated with MRSA bacteraemia?

Richard Brindle* and on behalf of Wessex Microbiologists{dagger}

Department of Microbiology, Portsmouth Hospitals, Portsmouth PO6 3LY, UK

Received 10 July 2009; returned 31 July 2009; revised 14 August 2009; accepted 16 August 2009

* Tel: +44-2392-286201; Fax: +44-2392-386395; E-mail: richard{at}brindle.com

Objectives: To establish whether local practice review and national methicillin-resistant Staphylococcus aureus (MRSA) treatment guidelines have increased the survival of patients with MRSA bacteraemia.

Methods: A multisite retrospective analysis of survival of patients with MRSA bacteraemia, which included patients from March 1995 to December 2008. Periods before and after the publication of UK guidelines were compared.

Results: Data were analysed for 1675 patients with a mean age of 69.8 years. Survival for the period up to and including 2003 was 64.3%, and was 62.8% for both 2004–2005 and 2006–2008.

Conclusions: No significant difference in survival in relation to local practice review or the publication of national guidelines was detected.

Keywords: S. aureus , mortality , retrospective

{dagger} Contributing members are listed in the Acknowledgements section.


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