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Journal of Antimicrobial Chemotherapy 2009 63(Supplement 1):i36-i40; doi:10.1093/jac/dkp081
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© The Author 2009. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

This article appears in the following Journal of Antimicrobial Chemotherapy issue: The changing face of febrile neutropenia-from monotherapy to moulds to mucositis [View the issue table of contents]

Articles

Mucositis: from febrile neutropenia to febrile mucositis

Nicole M. A. Blijlevens1,*, Richard M. Logan2 and Mihai G. Netea3

1 Department of Haematology, Radboud University Medical Center, PO Box 9101, NL-6500 HB Nijmegen, The Netherlands 2 Discipline of Oral Pathology, School of Dentistry, Faculty of Health Sciences, The University of Adelaide, Australia 3 Department of Medicine, Radboud University Medical Center, PO Box 9101, NL-6500 HB Nijmegen, The Netherlands

* Corresponding author. Tel: +31-24-361-47-62; Fax: +31-24-354-20-80; E-mail: N.Blijlevens{at}hemat.umcn.nl

The treatment of patients with cancer is often accompanied by life-threatening complications caused by chemotherapy and radiotherapy. They are known to result from neutropenia, but damage to the mucosal barrier as well as the humoral and cellular immune defences play a significant role in various infectious complications and aggravate diverse inflammatory processes. The article describes the journey from febrile neutropenia to febrile mucositis in patients treated with immunocompromising therapy.

Keywords: mucosal barrier injury , innate immunity , inflammation , cancer treatment , infections


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