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Journal of Antimicrobial Chemotherapy 2009 63(Supplement 1):i31-i35; doi:10.1093/jac/dkp080
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© The Author 2009. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

This article appears in the following Journal of Antimicrobial Chemotherapy issue: The changing face of febrile neutropenia-from monotherapy to moulds to mucositis [View the issue table of contents]

Articles

Moulds: diagnosis and treatment

Paul E. Verweij1,* and Johan Maertens2

1 Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands 2 Department of Haematology, University Hospital Gasthuisberg, Acute Leukaemia and Stem Cell Transplantation Unit, Herestraat 49, B-3000 Leuven, Belgium

* Corresponding author. Tel: +31-24-3614356; Fax: +31-24-3540216; E-mail: p.verweij{at}mmb.umcn.nl

Changes in fungal epidemiology and the emergence of resistance have increased the complexity of the management of patients with invasive fungal infections, as timely diagnosis and initiation of adequate antifungal therapy are key factors for improving outcomes. Therefore, alternative approaches to the empirical use of antifungal agents, which incorporate non-culture-based microbiological tools and high-resolution computed tomography of the chest, are under increasing investigation.

Keywords: invasive aspergillosis , laboratory diagnosis , empirical therapy , pre-emptive therapy


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